鸭运动时通气的化学反射驱动

Chemoreflex drive of ventilation during exercise in ducks.

作者信息

Faraci F M, Kiley J P, Fedde M R

出版信息

Pflugers Arch. 1984 Oct;402(2):162-5. doi: 10.1007/BF00583329.

PMID:6441923

Abstract

To determine if arterial chemoreceptors contribute to the ventilatory response during exercise, we measured minute ventilation (VI) in spontaneously breathing Pekin ducks (Anas platyrhynchos) during rest and running exercise when the inspired gas was switched from either 21% or 12% O2 to 100% O2 for 45 s (O2-test). In normoxia at rest (PaO2 = 99 Torr), inhaling 100% O2 reduced VI by 30%, while during resting hypoxic conditions (PaO2 = 56 Torr), 100% O2 inhalation reduced VI by 66%. During exercise, abruptly inhaling 100% O2 decreased VI by only 14% and 33% in normoxic and hypoxic conditions, respectively. Thus, only a small fraction of the ventilatory response during exercise under normoxic conditions is due to an arterial chemoreceptor input. However, during exercise in hypoxic conditions, arterial chemoreceptors provide a substantial portion of the total drive to ventilation.

摘要

为了确定动脉化学感受器是否在运动过程中对通气反应有贡献，我们在静息和跑步运动期间，测量了自发呼吸的北京鸭（绿头鸭）的分钟通气量（VI），此时吸入气体从21%或12% O₂切换为100% O₂并持续45秒（O₂测试）。在静息常氧状态下（动脉血氧分压 = 99托），吸入100% O₂使VI降低30%，而在静息低氧状态下（动脉血氧分压 = 56托），吸入100% O₂使VI降低66%。在运动期间，突然吸入100% O₂在常氧和低氧条件下分别仅使VI降低14%和33%。因此，在常氧条件下运动时，通气反应中只有一小部分是由于动脉化学感受器的输入。然而，在低氧条件下运动时，动脉化学感受器提供了通气总驱动力的很大一部分。