Okada R, Moshé S L, Albala B J
Brain Res. 1984 Aug;317(2):177-83. doi: 10.1016/0165-3806(84)90095-6.
The long-term effects of infantile seizures on the development of seizures in adulthood were studied in rats. Infantile seizures of varying severity were induced with intraperitoneal injections of kainic acid in 15-day-old rats. In adulthood the seizure susceptibility of the rats was determined by kindling the left amygdala and by measuring their ability to resist recurrent seizures. The results suggest that infantile status epilepticus is associated with a very high mortality; however in the surviving rats, infantile seizures even as severe as status epilepticus do not cause neuronal brain damage and do not predispose to the development of convulsions later in life.
在大鼠中研究了婴儿期癫痫发作对成年期癫痫发作发展的长期影响。通过向15日龄大鼠腹腔注射 kainic 酸诱导不同严重程度的婴儿期癫痫发作。成年后，通过点燃左杏仁核并测量大鼠抵抗反复癫痫发作的能力来确定其癫痫易感性。结果表明，婴儿期癫痫持续状态与极高的死亡率相关；然而，在存活的大鼠中，即使像癫痫持续状态那样严重的婴儿期癫痫发作也不会导致神经元脑损伤，也不会使它们在以后的生活中更容易发生惊厥。
