Becker K L, Nash D, Silva O L, Snider R H, Moore C F
Chest. 1981 Feb;79(2):211-6. doi: 10.1378/chest.79.2.211.
Serum and urinary calcitonin levels were measured in patients with acute and chronic inflammatory diseases of the lung. Using both carboxyl terminal and midportion antisera, the incidence of increased immunoreactive values of this hormone was 68 percent for patients with emphysema, 59 percent for tuberculosis, and 89 percent for acute bacterial pneumonitis. In order to determine the source of the high levels of calcitonin, immunoperoxidase stains were made of sections of human lung; the hormone was found within the bronchial Kultschitzky cell (K cell). This suggests a specific endocrine role for the K cell, and may explain not only the high calcitonin levels in patients with inflammatory lung disease, but also the high levels associated with both carcinoid tumor and small cell carcinoma, which may originate from K cells. It is apparent that moderately high levels of calcitonin in a patient with pulmonary disease cannot always be associated with tumor.
对患有肺部急慢性炎症疾病的患者测定了血清和尿液中的降钙素水平。使用羧基末端和中段抗血清，肺气肿患者中该激素免疫反应值升高的发生率为68%，肺结核患者为59%，急性细菌性肺炎患者为89%。为了确定降钙素高水平的来源，对人肺组织切片进行了免疫过氧化物酶染色；在支气管库尔契茨基细胞（K细胞）内发现了该激素。这表明K细胞具有特定的内分泌作用，这不仅可以解释肺部炎症疾病患者降钙素水平高的原因，还可以解释与类癌肿瘤和小细胞癌相关的高水平降钙素，这两种肿瘤可能起源于K细胞。显然，肺部疾病患者中降钙素水平适度升高并不总是与肿瘤有关。
