Reanney D C, Pressing J
J Mol Evol. 1984;21(1):72-5. doi: 10.1007/BF02100629.
Heat induces a number of premutational lesions (for example, the deamination of cytosine to uracil) in DNA and RNA. These kinds of errors occur in resting as well as replicating polynucleotides. However, an increase in temperature also raises the probability of copying error occurring in nucleic acids because of increased thermal noise in the replicative machinery. In most modern genetic systems, the majority of heat-induced lesions are efficiently repaired. It follows that the importance of heat-induced error increases as the effectiveness of repair declines. We show in this paper that the error rate of enzymatic polynucleotide copying is expected to increase monotonically with temperature. We also explore the effects of temperature variations on the early evolution of biological information transmission mechanisms.
热会在DNA和RNA中诱导产生许多前突变损伤（例如，胞嘧啶脱氨基变成尿嘧啶）。这类错误在静止的以及正在复制的多核苷酸中都会出现。然而，温度升高也会增加核酸复制错误发生的概率，因为复制机制中的热噪声增加了。在大多数现代遗传系统中，大多数热诱导损伤都能得到有效修复。因此，随着修复效率的下降，热诱导错误的重要性会增加。我们在本文中表明，酶促多核苷酸复制的错误率预计会随着温度单调增加。我们还探讨了温度变化对生物信息传递机制早期进化的影响。
