West C P, Baird D T
Scott Med J. 1984 Oct;29(4):212-7. doi: 10.1177/003693308402900402.
We describe the outcome of induction of ovulation with gonadotrophins (HMG/HCG) in 46 patients treated over 138 cycles. Ovulation was induced in 88 per cent of cycles and there were 43 conceptions in 33 patients with a cumulative conception rate of 96 per cent. The incidence of multiple pregnancy was 36 per cent of those reaching a gestation of 13 weeks or more and accounted for all the second and third trimester foetal losses. Overall, 61 per cent of the patients have taken home at least one healthy child. Mild symptomatic ovarian hyperstimulation complicated 9.4 per cent of courses and was more frequent among patients with normal pretreatment oestrogen levels. We found continuous biochemical monitoring of follicular growth to be a poor predictor of multiple pregnancy or hyperstimulation. We discuss our local experience with reference to published reports from other centres and in relation to recent advances in management and consider the future role of this therapy.
我们描述了46例患者在138个周期中使用促性腺激素（HMG/HCG）诱导排卵的结果。88%的周期成功诱导排卵，33例患者中有43次受孕，累积受孕率为96%。多胎妊娠发生率为妊娠13周及以上者的36%，且占所有孕中期和孕晚期胎儿丢失的原因。总体而言，61%的患者至少带回了一个健康的孩子。轻度症状性卵巢过度刺激综合征在9.4%的疗程中出现，且在预处理雌激素水平正常的患者中更常见。我们发现，对卵泡生长进行连续生化监测对多胎妊娠或过度刺激的预测效果不佳。我们结合其他中心发表的报告以及管理方面的最新进展讨论了我们当地的经验，并思考了这种治疗方法未来的作用。
