Faille A, Dresch C, Poirier O, Balitrand N, Najean Y
Scand J Haematol. 1978 Mar;20(3):280-6. doi: 10.1111/j.1600-0609.1978.tb02458.x.
Bone marrow from 17 patients with refractory anaemia with excess of myeloblasts (RAEM) was cultured in methylcellulose semi-solid medium. Compared with normal bone marrow, 3 patterns of growth occurred corresponding with different clinical stages of the condition. Patients whose bone marrow grew normal colonies and those who produced a predominance of microclusters had the longest life expectance, while those who produced a predominance of macroclusters had the shortest life expectancy with a high rate of acute leukaemic transformation. Colony culture appears to be a useful prognostic tool in the condition.
对17例伴有过多原始粒细胞的难治性贫血（RAEM）患者的骨髓在甲基纤维素半固体培养基中进行培养。与正常骨髓相比，出现了3种与病情不同临床阶段相对应的生长模式。骨髓生长出正常集落的患者以及产生大量微集落的患者预期寿命最长，而产生大量大集落的患者预期寿命最短，急性白血病转化发生率高。集落培养似乎是该病症中一种有用的预后工具。
