花生四烯酸在人子宫肌层和子宫颈中生物转化为前列腺素及相关化合物。

Bioconversion of arachidonic acid to prostaglandins and related compounds in human myometrium and uterine cervix.

作者信息

Mitsuhashi N, Kato J

出版信息

Endocrinol Jpn. 1984 Dec;31(6):815-20. doi: 10.1507/endocrj1954.31.815.

DOI:10.1507/endocrj1954.31.815

Abstract

Arachidonic Acid metabolites in human myometrium and uterine cervix were studied using silicic acid column chromatography, thin layer chromatography, reversed phase partition chromatography and gas-liquid chromatography. Myometrium produced 6-ketoPGF1 alpha, PGF2 alpha, PGE2, thromboxane B2. Uterine cervix produced 6-ketoPGF1 alpha, PGF2 alpha, PGE2, thromboxane B2, and one hydroxyacid. There was no difference between the rate of conversion of prostaglandins in myometrium and cervix. But only cervix could convert arachidonic acid to hydroxyacid.

摘要

利用硅酸柱色谱法、薄层色谱法、反相分配色谱法和气液色谱法，对人子宫肌层和子宫颈中的花生四烯酸代谢产物进行了研究。子宫肌层产生6-酮前列环素F1α、前列腺素F2α、前列腺素E2、血栓素B2。子宫颈产生6-酮前列环素F1α、前列腺素F2α、前列腺素E2、血栓素B2和一种羟酸。子宫肌层和子宫颈中前列腺素的转化率没有差异。但只有子宫颈能将花生四烯酸转化为羟酸。