用鸟氨酸脱羧酶抑制剂α-二氟甲基鸟氨酸成功治疗致死性原生动物感染。 - Suppr

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超能文献

Successful treatment of lethal protozoal infections with the ornithine decarboxylase inhibitor, alpha-difluoromethylornithine.

作者信息

Sjoerdsma A, Golden J A, Schechter P J, Barlow J L, Santi D V

出版信息

Trans Assoc Am Physicians. 1984;97:70-9.

PMID:6442954

Abstract

摘要

相似文献

Successful treatment of lethal protozoal infections with the ornithine decarboxylase inhibitor, alpha-difluoromethylornithine.用鸟氨酸脱羧酶抑制剂α-二氟甲基鸟氨酸成功治疗致死性原生动物感染。

Trans Assoc Am Physicians. 1984;97:70-9.

Pneumocystis carinii pneumonia treated with alpha-difluoromethylornithine. A prospective study among patients with the acquired immunodeficiency syndrome.用α-二氟甲基鸟氨酸治疗卡氏肺孢子虫肺炎。一项针对获得性免疫缺陷综合征患者的前瞻性研究。

West J Med. 1984 Nov;141(5):613-23.

Further studies on difluoromethylornithine in African trypanosomes.关于二氟甲基鸟氨酸在非洲锥虫中的进一步研究。

Med Biol. 1981 Dec;59(5-6):434-40.

Role of antibody in the elimination of trypanosomes after DL-alpha-difluoromethylornithine chemotherapy.DL-α-二氟甲基鸟氨酸化疗后抗体在锥虫清除中的作用。

J Parasitol. 1983 Oct;69(5):818-22.

Treatment of gambiense sleeping sickness in the Sudan with oral DFMO (DL-alpha-difluoromethylornithine), an inhibitor of ornithine decarboxylase; first field trial.在苏丹用口服鸟氨酸脱羧酶抑制剂二氟甲基鸟氨酸（DFMO）治疗冈比亚型昏睡病；首次现场试验。

Trans R Soc Trop Med Hyg. 1985;79(5):692-8. doi: 10.1016/0035-9203(85)90195-6.

Curative effect of alpha-difluoromethylornithine on fatal Trypanosoma congolense infection in mice.α-二氟甲基鸟氨酸对小鼠致死性刚果锥虫感染的疗效

Tropenmed Parasitol. 1982 Sep;33(3):161-2.

Inhibition of polyamine biosynthesis by alpha-difluoromethylornithine in African trypanosomes and Pneumocystis carinii as a basis of chemotherapy: biochemical and clinical aspects.α-二氟甲基鸟氨酸对非洲锥虫和卡氏肺孢子虫多胺生物合成的抑制作用作为化疗基础：生物化学与临床方面

Am J Trop Med Hyg. 1986 Nov;35(6):1153-6. doi: 10.4269/ajtmh.1986.35.1153.

Antagonism by polyamines of the curative effects of alpha-difluoromethylornithine in Trypanosoma brucei brucei infections.多胺对α-二氟甲基鸟氨酸治疗布氏布氏锥虫感染疗效的拮抗作用。

Biochem Pharmacol. 1981 Nov 1;30(21):3010-3. doi: 10.1016/0006-2952(81)90270-7.

Targeting the polyamine biosynthetic enzymes: a promising approach to therapy of African sleeping sickness, Chagas' disease, and leishmaniasis.靶向多胺生物合成酶：治疗非洲昏睡病、恰加斯病和利什曼病的一种有前景的方法。

Amino Acids. 2007 Aug;33(2):359-66. doi: 10.1007/s00726-007-0537-9. Epub 2007 Jul 4.

Catalytic irreversible inhibition of Trypanosoma brucei brucei ornithine decarboxylase by substrate and product analogs and their effects on murine trypanosomiasis.底物和产物类似物对布氏布氏锥虫鸟氨酸脱羧酶的催化不可逆抑制及其对小鼠锥虫病的影响。

Biochem Pharmacol. 1985 May 15;34(10):1773-7. doi: 10.1016/0006-2952(85)90648-3.

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Biochem J. 1986 Aug 1;237(3):685-9. doi: 10.1042/bj2370685.

Alterations in human circulating and bone marrow mononuclear cell polyamine levels in hematologic malignancies as a consequence of difluoromethylornithine administration.由于给予二氟甲基鸟氨酸导致血液系统恶性肿瘤患者循环和骨髓单个核细胞多胺水平的改变。

Invest New Drugs. 1988 Jun;6(2):125-34. doi: 10.1007/BF00195371.

Growth inhibition of pathogenic yeast isolates by alpha-difluoromethylornithine: an inhibition of ornithine decarboxylase.α-二氟甲基鸟氨酸对致病性酵母分离株的生长抑制作用：对鸟氨酸脱羧酶的抑制

Mycopathologia. 1987 Apr;98(1):3-8. doi: 10.1007/BF00431009.

Decarboxylation of alpha-difluoromethylornithine by ornithine decarboxylase.鸟氨酸脱羧酶催化α-二氟甲基鸟氨酸的脱羧反应。

Biochem J. 1987 Jan 1;241(1):305-7. doi: 10.1042/bj2410305.

Recent advances in the biochemistry of polyamines in eukaryotes.真核生物中多胺生物化学的最新进展。

Biochem J. 1986 Mar 1;234(2):249-62. doi: 10.1042/bj2340249.

Activity of lipid-soluble inhibitors of dihydrofolate reductase against Pneumocystis carinii in culture and in a rat model of infection.二氢叶酸还原酶的脂溶性抑制剂在体外培养及大鼠感染模型中对卡氏肺孢子虫的活性

Antimicrob Agents Chemother. 1987 Sep;31(9):1323-7. doi: 10.1128/AAC.31.9.1323.

Polyamine depletion and growth inhibition of Cryptococcus neoformans by alpha-difluoromethylornithine and cyclohexylamine.α-二氟甲基鸟氨酸和环己胺对新型隐球菌的多胺消耗及生长抑制作用

Mycopathologia. 1990 Oct;112(1):27-32. doi: 10.1007/BF01795176.

Polyamine regulation of heat-shock-induced spermidine N1-acetyltransferase activity.多胺对热休克诱导的亚精胺N1-乙酰转移酶活性的调节

Biochem J. 1990 May 1;267(3):601-5. doi: 10.1042/bj2670601.

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