多胺对α-二氟甲基鸟氨酸治疗布氏布氏锥虫感染疗效的拮抗作用。 - Suppr

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Antagonism by polyamines of the curative effects of alpha-difluoromethylornithine in Trypanosoma brucei brucei infections.

作者信息

Nathan H C, Bacchi C J, Hutner S H, Rescigno D, McCann P P, Sjoerdsma A

出版信息

Biochem Pharmacol. 1981 Nov 1;30(21):3010-3. doi: 10.1016/0006-2952(81)90270-7.

DOI:10.1016/0006-2952(81)90270-7

PMID:6797437

Abstract

摘要

相似文献

Antagonism by polyamines of the curative effects of alpha-difluoromethylornithine in Trypanosoma brucei brucei infections.多胺对α-二氟甲基鸟氨酸治疗布氏布氏锥虫感染疗效的拮抗作用。

Biochem Pharmacol. 1981 Nov 1;30(21):3010-3. doi: 10.1016/0006-2952(81)90270-7.

Novel combination chemotherapy of experimental trypanosomiasis by using bleomycin and DL-alpha-difluoromethylornithine; reversal by polyamines.

Biochem Pharmacol. 1982 Sep 1;31(17):2833-6. doi: 10.1016/0006-2952(82)90144-7.

Polyamine metabolism: a potential therapeutic target in trypanosomes.多胺代谢：锥虫潜在的治疗靶点。

Science. 1980 Oct 17;210(4467):332-4. doi: 10.1126/science.6775372.

Catalytic irreversible inhibition of Trypanosoma brucei brucei ornithine decarboxylase by substrate and product analogs and their effects on murine trypanosomiasis.底物和产物类似物对布氏布氏锥虫鸟氨酸脱羧酶的催化不可逆抑制及其对小鼠锥虫病的影响。

Biochem Pharmacol. 1985 May 15;34(10):1773-7. doi: 10.1016/0006-2952(85)90648-3.

Prevention by polyamines of the curative effect of amicarbalide and imidocarb for Trypanosoma brucei infections in mice.多胺对丁脒和咪唑苯脲治疗小鼠布氏锥虫感染疗效的预防作用

Biochem Pharmacol. 1981 Apr 15;30(8):883-6. doi: 10.1016/s0006-2952(81)80011-1.

Further studies on difluoromethylornithine in African trypanosomes.关于二氟甲基鸟氨酸在非洲锥虫中的进一步研究。

Med Biol. 1981 Dec;59(5-6):434-40.

Efficacy of combinations of difluoromethylornithine and bleomycin in a mouse model of central nervous system African trypanosomiasis.二氟甲基鸟氨酸与博来霉素联合用药在中枢神经系统非洲锥虫病小鼠模型中的疗效

Proc Natl Acad Sci U S A. 1983 Sep;80(18):5729-33. doi: 10.1073/pnas.80.18.5729.

Successful treatment of lethal protozoal infections with the ornithine decarboxylase inhibitor, alpha-difluoromethylornithine.用鸟氨酸脱羧酶抑制剂α-二氟甲基鸟氨酸成功治疗致死性原生动物感染。

Trans Assoc Am Physicians. 1984;97:70-9.

Curative effect of alpha-difluoromethylornithine on fatal Trypanosoma congolense infection in mice.α-二氟甲基鸟氨酸对小鼠致死性刚果锥虫感染的疗效

Tropenmed Parasitol. 1982 Sep;33(3):161-2.

DL-alpha-difluoromethylornithine (DFMO)-Berenil combination: therapeutic and prophylactic activity against Trypanosoma brucei brucei infection in mice.DL-α-二氟甲基鸟氨酸（DFMO）-贝尼尔组合：对小鼠布氏布氏锥虫感染的治疗和预防活性。

Rev Elev Med Vet Pays Trop. 1991;44(4):443-5.

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Oral putrescine restores virulence of ornithine decarboxylase-deficient Leishmania donovani in mice.口服腐胺可恢复鸟氨酸脱羧酶缺陷型杜氏利什曼原虫在小鼠体内的毒力。

Mol Biochem Parasitol. 2011 Apr;176(2):109-11. doi: 10.1016/j.molbiopara.2010.12.004. Epub 2010 Dec 21.

Dissecting the essentiality of the bifunctional trypanothione synthetase-amidase in Trypanosoma brucei using chemical and genetic methods.运用化学和遗传方法剖析布氏锥虫双功能硫醇嘌呤合酶-酰胺酶的必需性。

Mol Microbiol. 2009 Nov;74(3):529-40. doi: 10.1111/j.1365-2958.2009.06761.x. Epub 2009 Jun 24.

Proc Natl Acad Sci U S A. 1983 Sep;80(18):5729-33. doi: 10.1073/pnas.80.18.5729.

Effects of alpha-difluoromethylornithine on protein synthesis and synthesis of the variant-specific glycoprotein (VSG) in Trypanosoma brucei brucei.α-二氟甲基鸟氨酸对布氏布氏锥虫蛋白质合成及变异特异性糖蛋白（VSG）合成的影响

Biochem J. 1988 Feb 15;250(1):295-8. doi: 10.1042/bj2500295.

Putrescine uptake regulation in response to alpha-difluoromethylornithine treatment in Leishmania infantum promastigotes.婴儿利什曼原虫前鞭毛体中腐胺摄取调节对α-二氟甲基鸟氨酸处理的响应

Mol Cell Biochem. 1991 Oct 16;107(2):127-33. doi: 10.1007/BF00225516.

Cure of murine Trypanosoma brucei rhodesiense infections with an S-adenosylmethionine decarboxylase inhibitor.用S-腺苷甲硫氨酸脱羧酶抑制剂治愈小鼠布氏罗得西亚锥虫感染

Antimicrob Agents Chemother. 1992 Dec;36(12):2736-40. doi: 10.1128/AAC.36.12.2736.

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