Bahar M, Nunn J F, Rosen M, Flecknell P
Eur J Anaesthesiol. 1984 Mar;1(1):31-6.
Various concentrations of local anaesthetic agents have been injected into the rat and marmoset via a chronically implanted cannula in the subarachnoid space. In the rat, cocaine at a concentration of 0.125% produced analgesia without motor blockade whereas higher concentrations produced motor blockade in some animals. No clear differentiation could be shown with any concentrations of lignocaine or bupivacaine. In the marmoset, 0.125% cocaine resulted in sensory block in four out of five marmosets without motor blockade, whereas 0.25% cocaine produced motor block in two out of four marmosets. It would appear that differential blockade of sensory function without motor loss can be achieved by cocaine. New local anaesthetics based on cocaine or similar chemical structures would seem potentially valuable.
通过长期植入蛛网膜下腔的套管，将不同浓度的局部麻醉剂注射到大鼠和狨猴体内。在大鼠中，浓度为0.125%的可卡因产生镇痛作用而无运动阻滞，而较高浓度在一些动物中产生运动阻滞。任何浓度的利多卡因或布比卡因均未显示出明显的差异。在狨猴中，0.125%的可卡因导致五只狨猴中有四只出现感觉阻滞而无运动阻滞，而0.25%的可卡因在四只狨猴中有两只产生运动阻滞。似乎可卡因可以实现感觉功能的差异性阻滞而无运动丧失。基于可卡因或类似化学结构的新型局部麻醉剂似乎具有潜在价值。
