Lee G, Ikeda R, Herman I, Dwyer R M, Bass M, Hussein H, Kozina J, Mason D T
Am Heart J. 1983 Jun;105(6):885-9. doi: 10.1016/0002-8703(83)90384-8.
To determine the effects of laser irradiation upon human coronary atherosclerotic disease, coronary plaques were extracted from fresh human cadaver hearts. Seventy-four diseased artery samples were sectioned either transversely or longitudinally and subjected to laser treatment from argon-ion and carbon dioxide sources. The laser beam affected vaporization and patency in fibrous, lipoid, and calcified plaques as observed histologically. Calcified blockage showed greater extent of charred remnants following controlled thermal injury than did fibrous or lipoid obstructions. The area and depth of penetration varied directly with intensity and duration of photoirradiation and inversely with the density of the atherosclerotic tissue. This study supports further research work on the use of lasers to effect relief of atherosclerotic obstructions.
为了确定激光照射对人类冠状动脉粥样硬化疾病的影响，从新鲜的人类尸体心脏中提取冠状动脉斑块。74个患病动脉样本被横向或纵向切片，并接受来自氩离子和二氧化碳源的激光治疗。从组织学观察来看，激光束对纤维性、脂质和钙化斑块产生了汽化和通畅作用。与纤维性或脂质阻塞相比，钙化阻塞在控制性热损伤后显示出更大范围的烧焦残余物。穿透的面积和深度与光照射的强度和持续时间成正比，与动脉粥样硬化组织的密度成反比。这项研究支持进一步开展关于使用激光来缓解动脉粥样硬化阻塞的研究工作。
