Goette D K, Prescott C E
South Med J. 1978 May;71(5):505-8. doi: 10.1097/00007611-197805000-00009.
Two cases of late cutaneous syphilis are presented. After treatment for secondary syphilis in 1957 and retreatment for rising VDRL titers ten years later, one patient had developed a nodular syphilid. The other had several gummas. He had two quantitative nonreactive vDRL tests and a negative Treponema pallidum immobilization (TPI) test, but two reactive fluorescent treponemal antibody absorption (FTA-ABS) tests. Syphilis was suspected histologically and was confirmed by the specific serologic testing, the characteristic clinical presentation, and the prompt response to penicillin treatment. The clinical, serologic, histologic, therapeutic, and pathogenetic aspects of late benign syphilis of the skin are discussed.
本文报告两例晚期皮肤梅毒病例。一例患者于1957年接受二期梅毒治疗，十年后因VDRL滴度升高接受再次治疗，之后出现结节性梅毒疹。另一例有多个梅毒瘤。他的两次定量VDRL试验均为阴性，梅毒螺旋体制动试验（TPI）也为阴性，但荧光密螺旋体抗体吸收试验（FTA-ABS）有两次呈阳性。经组织学检查怀疑为梅毒，并通过特异性血清学检测、特征性临床表现及对青霉素治疗的迅速反应得以确诊。本文还讨论了晚期皮肤良性梅毒的临床、血清学、组织学、治疗及发病机制等方面。
