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丘疹结节性二期梅毒：一种经血清学和组织学检查确诊的罕见临床表型。

Papulonodular secondary syphilis: a rare clinic presentation confirmed by serologic and histologic exams.

作者信息

Veasey John Verrinder, Lellis Rute Facchini, Boin Maria Fernanda Feitosa de Camargo, Porto Pedro Loureiro, Chen Jessica Chia Sin

机构信息

Santa Casa de Misericórdia de São Paulo, São Paulo, SP, Brazil.

Private Practice, Londrina, PR, Brazil.

出版信息

An Bras Dermatol. 2016 Apr;91(2):205-7. doi: 10.1590/abd1806-4841.20163958.

DOI:10.1590/abd1806-4841.20163958
PMID:27192520
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4861568/
Abstract

Syphilis is a sexually transmitted disease caused by Treponema pallidum and divided into three stages according to the duration of the disease: primary, secondary and tertiary. Secondary syphilis has diverse clinical presentations, such as papular-nodular lesions. This presentation is rare, with 15 cases reported in the literature over the past 20 years. We report a case of secondary syphilis with papular-nodular lesions in a healthy 63-year-old patient, who has presented treponema in immunohistochemical examination of the skin lesions.

摘要

梅毒是一种由梅毒螺旋体引起的性传播疾病，根据病程分为三个阶段：一期、二期和三期。二期梅毒有多种临床表现，如丘疹结节性损害。这种表现较为罕见，在过去20年的文献中仅报道了15例。我们报告一例63岁健康患者出现丘疹结节性损害的二期梅毒病例，该患者在皮肤损害的免疫组化检查中发现了梅毒螺旋体。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/480e/4861568/469e21af3118/abd-91-02-0205-g03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/480e/4861568/7487bf9f4856/abd-91-02-0205-g01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/480e/4861568/08f75573eb8f/abd-91-02-0205-g02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/480e/4861568/469e21af3118/abd-91-02-0205-g03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/480e/4861568/7487bf9f4856/abd-91-02-0205-g01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/480e/4861568/08f75573eb8f/abd-91-02-0205-g02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/480e/4861568/469e21af3118/abd-91-02-0205-g03.jpg

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Papulonodular secondary syphilis: a rare clinic presentation confirmed by serologic and histologic exams.丘疹结节性二期梅毒：一种经血清学和组织学检查确诊的罕见临床表型。
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Immunohistochemical diagnosis of human infectious diseases: a review.免疫组织化学诊断人类传染病：综述。
Diagn Pathol. 2022 Jan 30;17(1):17. doi: 10.1186/s13000-022-01197-5.
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Corymbiform syphilis associated with three other sexually transmitted infections.花椰菜样梅毒合并其他三种性传播感染。

本文引用的文献

1
Treponema pallidum distribution patterns in mucocutaneous lesions of primary and secondary syphilis: an immunohistochemical and ultrastructural study.梅毒螺旋体在一期和二期梅毒黏膜皮肤损害中的分布模式：一项免疫组织化学和超微结构研究
Hum Pathol. 2009 May;40(5):624-30. doi: 10.1016/j.humpath.2008.10.017. Epub 2009 Jan 20.
2
Diagnosing Treponema pallidum in secondary syphilis by PCR and immunohistochemistry.通过聚合酶链反应（PCR）和免疫组织化学诊断二期梅毒中的梅毒螺旋体。
J Invest Dermatol. 2007 Oct;127(10):2345-50. doi: 10.1038/sj.jid.5700888. Epub 2007 Jun 7.
3
Secondary syphilitic lesions.
An Bras Dermatol. 2018 Jan-Feb;93(1):129-132. doi: 10.1590/abd1806-4841.20186850.
4
Papulonodular Secondary Syphilis Presenting as Multiple Distinct Cutaneous Lesions in an HIV-Positive Transgender Woman.丘疹结节性二期梅毒在一名HIV阳性的跨性别女性中表现为多个不同的皮肤病变。
Case Rep Dermatol. 2017 Mar 29;9(1):90-94. doi: 10.1159/000456065. eCollection 2017 Jan-Apr.
二期梅毒损害
Clin Microbiol Rev. 2005 Jan;18(1):205-16. doi: 10.1128/CMR.18.1.205-216.2005.