Bianchi L, Spichtin H P, Gudat F
Schweiz Med Wochenschr. 1983 Apr 9;113(14):478-84.
The present state of the art in non-A, non-B hepatitis is reviewed. Eight years of world-wide efforts in research have not yielded a definite characterization of agent(s) and markers of this viral infection. Diagnosis is therefore established mainly by exclusion of the hepatitis viruses A and B, Epstein-Barr virus and cytomegalovirus, and drug-induced liver disease. Currently available serological, electron microscopic, immune electron microscopic and clinical information on non-A, non-B hepatitis in chimpanzee and man is briefly reviewed. Some light microscopic features provisionally regarded as suggestive of non-A, non-B hepatitis in man are presented. In daily practice the diagnostic tools in the near future will largely depend upon progress in the elaboration of suitable serological test systems and on further confirmation of microscopic findings, unless an unexpected breakthrough occurs through identification and characterization of the virus(es) in non-A, non-B infection.
本文综述了非甲非乙型肝炎的当前技术现状。全球八年的研究努力尚未明确该病毒感染的病原体及其标志物。因此，诊断主要通过排除甲型和乙型肝炎病毒、爱泼斯坦-巴尔病毒、巨细胞病毒以及药物性肝病来确立。本文简要回顾了目前关于黑猩猩和人类非甲非乙型肝炎的血清学、电子显微镜、免疫电子显微镜及临床信息。文中还介绍了一些暂被认为提示人类非甲非乙型肝炎的光镜特征。在日常实践中，除非在非甲非乙感染中通过病毒鉴定和特征描述取得意外突破，否则近期的诊断工具很大程度上将依赖于合适血清学检测系统研发的进展以及显微镜检查结果的进一步证实。
