Edmondson H T, Moore W L, Rissing J P, Crockett J K
South Med J. 1978 May;71(5):533-7. doi: 10.1097/00007611-197805000-00016.
The combination of clindamycin phosphate and gentamicin sulfate in treating 53 patients with a variety of serious infections was studied. Initial cultures of specimens from 31 patients yielded both anaerobic and aerobic pathogens. Eleven cultures showed only anaerobic organisms and 11 showed only aerobes. Of patients treated with clindamycin and gentamicin and surgical intervention, 87.8% had bacteriologic cure. Clinical response was poor in only two cases. Two patients developed rash and one had diarrhea, but no reactions suggestive of pseudomembranous colitis were seen.
对磷酸克林霉素和硫酸庆大霉素联合治疗53例各种严重感染患者的情况进行了研究。31例患者标本的初始培养物中分离出了厌氧和需氧病原体。11份培养物仅显示有厌氧生物，11份仅显示有需氧生物。接受克林霉素和庆大霉素治疗并进行手术干预的患者中，87.8%实现了细菌学治愈。仅2例患者临床反应不佳。2例患者出现皮疹，1例出现腹泻，但未观察到提示伪膜性结肠炎的反应。
