饮食对大鼠肝脏中1,2 - 二甲基肼代谢的影响。

Influence of diet on 1,2-dimethylhydrazine metabolism in rat liver.

作者信息

Wolter S, Schmähl D, Frank N

出版信息

Nutr Cancer. 1984;6(3):181-6. doi: 10.1080/01635588509513822.

Abstract

The metabolism of 1,2-dimethylhydrazine (DMH) was investigated in isolated perfused livers excised from Sprague-Dawley rats fed four semisynthetic diets over two generations. The diets were varied within normal physiological limits, without producing specific deficiencies. Diet was shown to have an influence on the growth of animals and on the cholesterol content and beta-glucuronidase activity in the blood serum. However, diet did not influence the rate of metabolism of DMH or the concentration of metabolites.

摘要

在两代时间里，用四种半合成饲料喂养斯普拉格-道利大鼠，然后从这些大鼠身上切除肝脏，制成离体灌注肝脏，以此研究1,2 - 二甲基肼（DMH）的代谢情况。饲料在正常生理限度内变化，未产生特定缺乏症。结果表明，饲料对动物生长以及血清中的胆固醇含量和β - 葡萄糖醛酸酶活性有影响。然而，饲料并不影响DMH的代谢速率或代谢物浓度。