Haeusler G
J Hypertens Suppl. 1984 Dec;2(3):S73-5.
Reactivity to noradrenaline was studied in isolated perfused mesenteric artery preparations from 14-week-old spontaneously hypertensive rats (SHR), DOCA/salt and one-kidney, one clip hypertensive rats as well as in rats which did not develop high blood pressure due to intracerebroventricular (i.c.v.) injection of 6-hydroxydopamine (6-OH-DA) at an age of five to six weeks. The mesenteric arteries from all three types of hypertensive rats showed an increased reactivity to noradrenaline as characterized by a steeper dose-response curve and elevated maximal vasoconstriction when compared with normotensive controls. 6-OH-DA-induced failure to develop DOCA/salt or renal hypertension was associated with vascular reactivity indistinguishable from that of normotensive controls. Mesenteric arteries from 6-OH-DA-treated SHR showed an increased reactivity to noradrenaline but no increase in maximal vasoconstriction. It is concluded that vascular reactivity of SHR to noradrenaline is increased at an age of 14 weeks although elevated blood pressure can be excluded as causative factor.
研究了14周龄自发性高血压大鼠（SHR）、去氧皮质酮/盐型高血压大鼠和单肾单夹型高血压大鼠以及在5至6周龄时因脑室内注射6-羟基多巴胺（6-OH-DA）而未发生高血压的大鼠的离体灌注肠系膜动脉制剂对去甲肾上腺素的反应性。与正常血压对照组相比，所有三种类型高血压大鼠的肠系膜动脉对去甲肾上腺素的反应性均增加，表现为剂量反应曲线更陡峭，最大血管收缩增强。6-OH-DA诱导的去氧皮质酮/盐型或肾性高血压的不发生与血管反应性与正常血压对照组无差异有关。经6-OH-DA处理的SHR的肠系膜动脉对去甲肾上腺素的反应性增加，但最大血管收缩未增加。结论是，14周龄时SHR对去甲肾上腺素的血管反应性增加，尽管可排除血压升高作为致病因素。
