Vankeerberghen L, Oppenheimer M, Opolon P, Lévy V G
Liver Unit, Hôpital Saint-Antoine, INSERM U9, Paris, France.
Life Support Syst. 1983;1 Suppl 1:106-11.
Two female patients with grade IV primary biliary cirrhosis, untractable pruritus, arthralgias and xanthomatous neuropathy in one case, underwent long term plasmapheresis for 30 months (on a continuous centrifugation cell separator) and 18 months (on capillary plasma filters). Plasma exchange were performed monthly and substitution achieved by diluted human serum albumin. No major side effect occurred. Pruritus, arthralgias and xanthomatous neuropathy greatly improved or even disappeared. The plasma levels of transaminases, albumin, globulin and clotting factors were stable, alkaline phosphatases slightly diminished. Bilirubin, after an initial fall at 6 months, increased again. Cholesterol stabilized at near normal values. Bile acids blood levels decreased in both cases.
两名患有IV级原发性胆汁性肝硬化的女性患者，其中一例伴有难治性瘙痒、关节痛和黄瘤性神经病变，分别接受了30个月（使用连续离心细胞分离器）和18个月（使用毛细管血浆滤器）的长期血浆置换。每月进行一次血浆置换，用稀释的人血清白蛋白进行替代。未发生重大副作用。瘙痒、关节痛和黄瘤性神经病变有很大改善甚至消失。转氨酶、白蛋白、球蛋白和凝血因子的血浆水平稳定，碱性磷酸酶略有下降。胆红素在最初6个月下降后又再次升高。胆固醇稳定在接近正常的值。两例患者的血胆汁酸水平均下降。
