Sturtevant F M
Pediatrics. 1980 Mar;65(3):610-3.
Acrodermatitis enteropathica, a heritable disease of zinc deficiency, was formerly amenable to treatment only with dihaloquinolinol drugs. A few cases of optic atrophy were reported in surviving patients and were proposed as examples of ocular drug toxicity, principally because of the association between iodochlorhydroxyquin and subacute myelo-optic neuropathy (SMON) in Japan. An alternate hypothesis is now offered: that the optic atrophy was secondary to the zinc deficiency, which is consistent with diverse evidence cited from the literature. Therefore, it would seem worthwhile to investigate zinc in cases of disk pallor described as idiopathic or drug associated, and to investigate visual function in cases of severe malnourishment.
肠病性肢端皮炎是一种遗传性锌缺乏疾病，以前仅用二卤喹诺醇类药物治疗。有几例存活患者出现视神经萎缩的报道，并被认为是眼部药物毒性的例子，主要是因为在日本，碘氯羟喹与亚急性脊髓视神经病变（SMON）有关。现在提出另一种假说：视神经萎缩是锌缺乏的继发表现，这与文献中引用的各种证据一致。因此，对于被描述为特发性或药物相关性视盘苍白的病例，研究锌的情况似乎是值得的；对于严重营养不良的病例，研究其视觉功能似乎也是值得的。
