Leavitt F, Garron D C, Whisler W W, D'Angelo C M
Clin Orthop Relat Res. 1980 Jan-Feb(146):136-43.
Seventy-seven patients treated by chymopapain and laminectomy were compared before, and 6 and 14 weeks after, treatment. A standardized, multidimensional scale of low back pain providing scores on 7 independent dimensions of sensory and affective discomfort and one measure of intensity were used. Fourteen weeks after surgery, patients treated by chymopapain were functioning as well as those treated by laminectomy. Major differences, however, characterized the course of recovery. Chymopapain produced rapid change, which was maintained over the 3 1/2-month period. Healing following laminectomy was slower, but the end results were essentially the same. These findings, using sophisticated measurement techniques, support previous research suggesting that chymopapain is an effective alternative to laminectomy in the treatment of lumbar disk disease.
对77例接受木瓜凝乳蛋白酶治疗和椎板切除术的患者在治疗前、治疗后6周和14周进行了比较。使用了一种标准化的多维下背痛量表，该量表在感觉和情感不适的7个独立维度上给出分数，并给出了一个强度测量值。手术后14周，接受木瓜凝乳蛋白酶治疗的患者与接受椎板切除术的患者功能相同。然而，恢复过程存在重大差异。木瓜凝乳蛋白酶产生了快速变化，并在3个半月的时间里保持不变。椎板切除术后的愈合较慢，但最终结果基本相同。这些使用复杂测量技术的发现支持了先前的研究，表明木瓜凝乳蛋白酶在治疗腰椎间盘疾病方面是椎板切除术的有效替代方法。
