Cox K O, Cox J
Aust J Exp Biol Med Sci. 1981 Feb;59(1):55-61. doi: 10.1038/icb.1981.2.
Autoantibodies and autoantibody-specific suppressor cells are produced in mice injected with RBC from rats. In this report it is shown, first, that the RBC from various strains of rats stimulate similar clones of auto-reactive B-cells. The evidence for this conclusion was obtained using antibodies eluted from the RBC and sera from mice positive in direct Coombs' tests. Autoantibodies elicited by RBC from any strain of rat were absorbed by RBC from all strains of rat tested but not by sheep RBC. Secondly, it is shown that spleen cells from mice injected with RBC of one strain of rat delayed autoantibody production elicited by RBC from syngeneic and allogeneic rats when transferred to syngeneic mice before the first injection of rat RBC. Serum antibody levels to rat RBC were not reduced.
给小鼠注射大鼠红细胞后，小鼠体内会产生自身抗体和自身抗体特异性抑制细胞。在本报告中，首先表明，来自不同品系大鼠的红细胞刺激相似的自身反应性B细胞克隆。该结论的证据是使用从红细胞洗脱的抗体以及直接抗人球蛋白试验呈阳性的小鼠血清获得的。任何品系大鼠的红细胞引发的自身抗体都可被所测试的所有品系大鼠的红细胞吸收，但不能被绵羊红细胞吸收。其次，表明在首次注射大鼠红细胞之前，将注射了一个品系大鼠红细胞的小鼠的脾细胞转移到同基因小鼠中，会延迟同基因和异基因大鼠红细胞引发的自身抗体产生。针对大鼠红细胞的血清抗体水平并未降低。
