Eskenasy A
Morphol Embryol (Bucur). 1980 Apr-Jun;26(2):133-43.
Different types of lesions in small bronchi and bronchioli in a hundred lungs or lobes resected for chronic lung diseases (suppurations, chronic pneumonitides, tumours) were evidenced and interpreted in the light of experimental results and in relation to the lung processes in their entirety. Inflammatory, exudative and proliferative lesions, primary and secondary changes, as well as evolutive modifications were discerned. Their structural analysis demonstrated the influence of persisting aerogenic agents of the infections, antigenic or common types, some correlations with the surrounding parenchyma primarily or secondarily involved, and possible mechanisms determining the lesions of small bronchi and bronchioli. Inflammatory changes of the lung tissue following those of bronchi are evident within chronic suppurations with or without bronchiolectasias, with a varied restructuration of the lung tissue. The role of the immunopathogenic component was emphasized not only in chronic pneumonitides, but also in other cases. Proliferative changes of respiratory bronchioli were only rarely found in distal zones of lungs resected for tumours. Relationships between bronchiolar lesions and parenchymatous changes of the centrolobular emphysema type were never evidenced in the analysed cases.
对因慢性肺部疾病（化脓性病变、慢性肺炎、肿瘤）而切除的100个肺或肺叶中的小支气管和细支气管内不同类型的病变进行了观察，并根据实验结果以及与整个肺部病变过程的关系进行了解释。观察到了炎症性、渗出性和增殖性病变、原发性和继发性变化以及演变性改变。对其结构分析表明，感染的持续性气源性病原体（抗原性或常见类型）产生了影响，与主要或次要受累的周围实质存在一些相关性，以及决定小支气管和细支气管病变的可能机制。在伴有或不伴有细支气管扩张的慢性化脓性病变中，支气管病变后肺组织的炎症变化明显，肺组织有不同程度的重构。免疫致病成分的作用不仅在慢性肺炎中得到强调，在其他病例中也是如此。在因肿瘤而切除的肺的远端区域，仅很少发现呼吸性细支气管的增殖性变化。在所分析的病例中，从未发现细支气管病变与小叶中心型肺气肿的实质变化之间存在关联。
