Delafuente J C, Bethea L N, Panush R S
Ann Allergy. 1980 Jun;44(6):331-4.
Atopic diseases are often characterized by high IgE levels and impaired cellular immune function. Defects in regulatory immune mechanisms have been identified in many other immunologic diseases. The authors examined non-specific spontaneous and concanavalin A generated suppressor function in 15 atopic patients using a new, simplified assay for suppressor cell function. Although three patients exhibited high spontaneous but little con A induced suppressor cell activity, there was no over-all difference in suppression between the atopic and normal control groups.
特应性疾病通常以高IgE水平和细胞免疫功能受损为特征。在许多其他免疫疾病中已发现调节免疫机制存在缺陷。作者使用一种新的、简化的抑制细胞功能检测方法，检测了15名特应性患者的非特异性自发和伴刀豆球蛋白A诱导的抑制功能。尽管有三名患者表现出高自发但伴刀豆球蛋白A诱导的抑制细胞活性较低，但特应性患者组和正常对照组之间在抑制方面没有总体差异。
