实验性脑膜炎期间大观霉素在脑脊液中的穿透情况。 （注：原文中“duirng”拼写错误，应为“during”）
Penetration of spectinomycin into cerebrospinal fluid duirng experimental meningitis.
作者信息
Delgado D G, Brau C J, Avent C K
出版信息
Antimicrob Agents Chemother. 1980 Feb;17(2):286-7. doi: 10.1128/AAC.17.2.286.
Abstract
The concentration of spectinomycin in serum and cerebrospinal fluid was compared in rabbits with and without experimental pneumococcal meningitis. When injected intravenously, spectinomycin could not be detected in the cerebrospinal fluid of normal rabbits. In rabbits with meningeal inflammation, however, spectinomycin penetrated the blood-brain barrier and produced significant cerebrospinal fluid concentrations, equal to or well above spectinomycin minimal inhibitory concentrations for many bacterial species.
摘要
在患有和未患有实验性肺炎球菌性脑膜炎的兔子中比较了血清和脑脊液中壮观霉素的浓度。静脉注射时，正常兔子的脑脊液中检测不到壮观霉素。然而，在患有脑膜炎症的兔子中，壮观霉素穿透了血脑屏障并产生了显著的脑脊液浓度，该浓度等于或远高于许多细菌种类的壮观霉素最低抑菌浓度。
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Penetration of spectinomycin into cerebrospinal fluid duirng experimental meningitis.实验性脑膜炎期间大观霉素在脑脊液中的穿透情况。 （注：原文中“duirng”拼写错误，应为“during”）
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本文引用的文献
1
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Ann N Y Acad Sci. 1966 Jun 14;132(2):984-91. doi: 10.1111/j.1749-6632.1966.tb43021.x.
2
Simplified, accurate method for antibiotic assay of clinical specimens.临床标本抗生素检测的简化、准确方法。
Appl Microbiol. 1966 Mar;14(2):170-7. doi: 10.1128/am.14.2.170-177.1966.
3
In vitro antibacterial activity of spectinomycin.壮观霉素的体外抗菌活性。
Antimicrob Agents Chemother. 1972 Dec;2(6):427-30. doi: 10.1128/AAC.2.6.427.
4
New antibiotics: epicillin, minocycline and spectinomycin a summary of their antibacterial activity, pharmacokinetic properties and therapeutic efficacy.
Drugs. 1972;3(5):314-30. doi: 10.2165/00003495-197203050-00002.
5
Absorption, distribution, and elimination of spectinomycin dihydrochloride in man.
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6
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7
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