McCormack W M, Finland M
Ann Intern Med. 1976 Jun;84(6):712-6. doi: 10.7326/0003-4819-84-6-712.
A single intramuscular injection of 0.2 g of spectinomycin hydrochloride is highly effective for the treatment of uncomplicated anogenital infections with Neisseria gonorrhoeae. Spectinomycin hydrochloride is indicated for uncomplicated anogenital gonococcal infections in men and women who cannot receive penicillin or probenecid, and is the drug of choice for the retreatment of patients with uncomplicated anogenital gonococcal infection who have not responded to other antibiotics. A single dose of spectinomycin does not appear to be reliably effective in the treatment of gonococcal pharyngitis. Preliminary reports indicate that multiple-dose schedules of spectinomycin will prove to be effective in gonococcal pelvic inflammatory disease and disseminated gonococcal infection. In the dosage used for gonococcal infections, spectinomycin has little effect on infection with Treponema pallidum. Evaluation of this antibiotic against other microorganisms suggests little utility for this agent in conditions other than gonococcal infections.
单次肌内注射0.2克盐酸大观霉素对治疗由淋病奈瑟菌引起的单纯性肛门生殖器感染非常有效。盐酸大观霉素适用于不能使用青霉素或丙磺舒的男性和女性的单纯性肛门生殖器淋球菌感染，并且是对其他抗生素无反应的单纯性肛门生殖器淋球菌感染患者再治疗的首选药物。单剂量大观霉素似乎对淋菌性咽炎的治疗没有可靠疗效。初步报告表明，多剂量的大观霉素方案将被证明对淋菌性盆腔炎和播散性淋球菌感染有效。在用于淋球菌感染的剂量下，大观霉素对梅毒螺旋体感染几乎没有影响。对这种抗生素针对其他微生物的评估表明，除了淋球菌感染外，该药物在其他情况下几乎没有用处。
