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表皮生长因子的促生长活性可被佛波酯中和。

EGF growth promoting activity is neutralized by phorbol esters.

作者信息

Lechner J F, Kaighn M E

出版信息

Cell Biol Int Rep. 1980 Jan;4(1):23-8. doi: 10.1016/0309-1651(80)90005-3.

DOI:10.1016/0309-1651(80)90005-3
PMID:6446408
Abstract

The tumor-promoter, TPA, stimulates growth of human epithelial cells but not that of normal fibroblasts. In the presence of either EGF or FGF, TPA antagonizes the growth stimulatory activity of both factors in both cell lines.

摘要

肿瘤促进剂佛波酯（TPA）可刺激人上皮细胞生长，但对正常成纤维细胞无此作用。在表皮生长因子（EGF）或成纤维细胞生长因子（FGF）存在的情况下，TPA可拮抗这两种因子对两种细胞系的生长刺激活性。

相似文献

1
EGF growth promoting activity is neutralized by phorbol esters.表皮生长因子的促生长活性可被佛波酯中和。
Cell Biol Int Rep. 1980 Jan;4(1):23-8. doi: 10.1016/0309-1651(80)90005-3.
2
Antagonism between epidermal growth factor and phorbol ester tumor promoters in human breast cancer cells.人乳腺癌细胞中表皮生长因子与佛波酯肿瘤启动子之间的拮抗作用。
J Clin Invest. 1981 Apr;67(4):943-51. doi: 10.1172/jci110144.
3
Binding of epidermal growth factor to primary and permanent cultures of mouse epidermal cells: inhibition by tumor-promoting phorbol esters.表皮生长因子与小鼠表皮细胞原代培养物和永久培养物的结合：促癌佛波酯的抑制作用
Cancer Lett. 1979 Jul;7(2-3):71-7. doi: 10.1016/s0304-3835(79)80098-1.
4
Growth stimulation of hamster embryonic fibroblasts by phorbol esters.佛波酯对仓鼠胚胎成纤维细胞的生长刺激作用。
Gan. 1980 Dec;71(6):871-4.
5
Tumor promoter-induced inhibition of epidermal growth factor binding to cultured mouse primary epidermal cells.肿瘤启动子诱导的表皮生长因子与培养的小鼠原代表皮细胞结合的抑制作用。
Cancer Res. 1981 Jun;41(6):2308-14.
6
Effects of 12-O-tetradecanoyl phorbol-13-acetate and epidermal growth factor on the proliferation of human mutant fibroblasts in vitro.12-O-十四烷酰佛波醇-13-乙酸酯和表皮生长因子对人突变成纤维细胞体外增殖的影响。
Cancer Lett. 1981 Sep;13(4):315-23. doi: 10.1016/0304-3835(81)90060-4.
7
Stimulation of DNA synthesis by transient exposure of cell cultures to TPA or polypeptide mitogens: induction of competence or incomplete removal?通过将细胞培养物短暂暴露于佛波酯（TPA）或多肽有丝分裂原刺激DNA合成：诱导感受态还是不完全去除？
J Cell Physiol. 1981 Oct;109(1):99-109. doi: 10.1002/jcp.1041090112.
8
Effect of 12-O-tetradecanoylphorbol-13-acetate (TPA) on the growth inhibitory and increased phosphatidylinositol (PI) responses induced by epidermal growth factor (EGF) in A431 cells.12-O-十四烷酰佛波醇-13-乙酸酯（TPA）对表皮生长因子（EGF）诱导的A431细胞生长抑制及磷脂酰肌醇（PI）反应增强的影响。
J Cell Physiol. 1983 Oct;117(1):91-100. doi: 10.1002/jcp.1041170113.
9
Phorbol esters stimulate growth and inhibit differentiation in cultured thyroid cells.佛波酯可刺激培养的甲状腺细胞生长并抑制其分化。
Endocrinology. 1985 Apr;116(4):1603-9. doi: 10.1210/endo-116-4-1603.
10
Phorbol ester and mitogens stimulate human fibroblast secretions of plasmin-activatable plasminogen activator and protease nexin, an antiactivator/antiplasmin.佛波酯和促细胞分裂剂可刺激人成纤维细胞分泌纤溶酶激活的纤溶酶原激活剂和蛋白酶连接蛋白，一种抗激活剂/抗纤溶酶。
J Cell Biol. 1983 Aug;97(2):323-8. doi: 10.1083/jcb.97.2.323.

引用本文的文献

1
Inhibition of protein breakdown by epidermal growth factor in IMR90 human fibroblasts and other mammalian cell lines.表皮生长因子对IMR90人成纤维细胞及其他哺乳动物细胞系中蛋白质分解的抑制作用。
Biochem J. 1983 Jan 15;210(1):251-8. doi: 10.1042/bj2100251.
2
Effects of epidermal growth factor and 12-O-tetradecanoylphorbol-13-acetate on metabolism of the epidermal growth factor receptor in normal human fibroblasts.表皮生长因子和十四酰佛波醇乙酸酯对正常人成纤维细胞中表皮生长因子受体代谢的影响。
Mol Cell Biol. 1984 Sep;4(9):1718-24. doi: 10.1128/mcb.4.9.1718-1724.1984.
3
Epidermal growth factor is synergistic with phorbol esters and vasopressin in stimulating arachidonate release and prostaglandin production in renal glomerular mesangial cells.
表皮生长因子在刺激肾小球系膜细胞释放花生四烯酸和产生前列腺素方面与佛波酯及加压素具有协同作用。
Biochem J. 1988 Jan 15;249(2):587-92. doi: 10.1042/bj2490587.
4
Allosteric regulation of the epidermal growth factor receptor kinase.表皮生长因子受体激酶的变构调节
J Cell Biol. 1986 Dec;103(6 Pt 1):2067-72. doi: 10.1083/jcb.103.6.2067.
5
Control of growth and squamous differentiation in normal human bronchial epithelial cells by chemical and biological modifiers and transferred genes.化学和生物修饰剂及转移基因对正常人支气管上皮细胞生长和鳞状分化的调控
Environ Health Perspect. 1989 Mar;80:209-20. doi: 10.1289/ehp.8980209.