Osswald F, Gloor M, Steinbacher M, Franke M
Z Hautkr. 1980 Jan 1;55(1):30-4.
It was shown by in vitro studies that 8-methoxypsoralen (= 8 MOP) alone and UVA irradiation alone produces relatively little inhibition of the growth of Propionibacterium acnes and Propionibacterium granulosum, whereas a combination leads to an intense suppression of bacterial growth. It was further demonstrated by in vivo studies on 14 subjects that local treatment with 8 MOP and UVA significantly reduces the propionibacteria in the pilosebaceous duct. These results afford a possible explanation for the well known favorable effect of photochemotherapy on acne vulgaris. In addition, they contribute to explaining the drier appearance of the skin after photochemotherapy.
体外研究表明，单独使用8-甲氧基补骨脂素（= 8-MOP）和单独进行紫外线A（UVA）照射对痤疮丙酸杆菌和颗粒丙酸杆菌的生长抑制作用相对较小，而两者联合使用则会导致细菌生长受到强烈抑制。对14名受试者的体内研究进一步证明，用8-MOP和UVA进行局部治疗可显著减少毛囊皮脂腺导管中的丙酸杆菌。这些结果为光化学疗法对寻常痤疮的众所周知的良好效果提供了一种可能的解释。此外，它们有助于解释光化学疗法后皮肤外观更干燥的现象。
