Peyramond D, Bensahkoun D, Bertrand J L
Arch Fr Pediatr. 1980 Apr;37(4):219-25.
Sixteen children with "scalded skin" due to staphylococcal infections are described [six cases of staphylococcal scarlet fever, 6 cases of bullous impetigo and 4 cases of toxic epidermal necrolysis (Lyell's disease--of which Ritter's disease is only the neonatal manifestation)]. The clinical features of each of these conditions are described, the common feature being the severity of the pathological changes. The role of the exfoliating toxin secreted by the pathogenic staphylococci mostly belonging to phagegroup II, phagetype 3A, 3N, 3C, 55 or 71) is emphasized. Treatment should be aimed at reducing secondary infection by strict asepsis and by eradicating staphylococci with appropriate antibiotic therapy. Corticosteroids have no beneficial effect. The outcome is good if these principles are applied strictly.
本文描述了16例因葡萄球菌感染导致“皮肤烫伤样综合征”的儿童病例[6例葡萄球菌性猩红热、6例大疱性脓疱病和4例中毒性表皮坏死松解症(莱尔病——其中里特尔病仅为新生儿表现)]。文中描述了每种病症的临床特征,其共同特点是病理变化严重。强调了主要属于噬菌体Ⅱ组、噬菌体型3A、3N、3C、55或71的致病性葡萄球菌所分泌的剥脱毒素的作用。治疗应旨在通过严格的无菌操作减少继发感染,并通过适当的抗生素治疗根除葡萄球菌。皮质类固醇没有有益作用。如果严格遵循这些原则,预后良好。