美洛西林在肾功能损害患者中的药代动力学。
Mezlocillin pharmacokinetics in renal impairment.
作者信息
Aronoff G R, Sloan R S, Luft F C, Nelson R L, Maxwell D R, Kleit S A
出版信息
Clin Pharmacol Ther. 1980 Oct;28(4):523-8. doi: 10.1038/clpt.1980.197.
Mezlocillin kinetics was examined in 28 adult subjects with varying renal function. Mezlocillin 3 gm, was infused over 30 min. Mean peak plasma concentrations ranged from 204 to 253 mg/I. When the area under the curve (AUC) was plotted against creatinine clearance (CCr), the relationship found was expressed by the equation AUC = 656e(-0.01)(CCr). From this relationship a dosage nonogram was derived describing a power function with the following equaton: Dose fraction = 1.32--e(-0.01)(CCr). Therapeutic guidelines are suggested.
在28名肾功能各异的成年受试者中研究了美洛西林的动力学。3克美洛西林在30分钟内输注完毕。血浆平均峰值浓度在204至253毫克/升之间。当将曲线下面积（AUC）与肌酐清除率（CCr）作图时，发现的关系由方程AUC = 656e（-0.01）（CCr）表示。根据这种关系得出了一个剂量列线图，描述了具有以下方程的幂函数：剂量分数 = 1.32 - e（-0.01）（CCr）。提出了治疗指南。
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