美洛西林在兔体内的肠道吸收情况。
Mezlocillin enteral absorption in rabbits.
作者信息
Lavelle K J, Brier M E, Aronoff G R
出版信息
Antimicrob Agents Chemother. 1981 Sep;20(3):418-9. doi: 10.1128/AAC.20.3.418.
Abstract
To determine the role of enterohepatic recirculation on its nonlinear elimination, we studied the enteral absorption of mezlocillin in rabbits. Mezlocillin was not substantially absorbed from the stomach or duodenum. We conclude that enterohepatic recirculation does not cause the dose-dependent elimination kinetics of mezlocillin.
摘要
为了确定肠肝循环在美洛西林非线性消除中的作用，我们研究了美洛西林在兔体内的肠吸收情况。美洛西林在胃或十二指肠中基本不被吸收。我们得出结论，肠肝循环不会导致美洛西林出现剂量依赖性消除动力学。
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Clin Pharmacol Ther. 1980 Oct;28(4):523-8. doi: 10.1038/clpt.1980.197.
2
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Antimicrob Agents Chemother. 1978 Dec;14(6):801-6. doi: 10.1128/AAC.14.6.801.
3
Mezlocillin pharmacokinetics in patients with normal and impaired renal functions.正常肾功能和肾功能受损患者的美洛西林药代动力学。
Antimicrob Agents Chemother. 1979 Nov;16(5):651-4. doi: 10.1128/AAC.16.5.651.
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