Kramer W G, Pickering L K, Culbert S, Frankel L S
Antimicrob Agents Chemother. 1984 Jan;25(1):62-4. doi: 10.1128/AAC.25.1.62.
The pharmacokinetics of mezlocillin were studied in 31 children (age, 2 to 19 years) with malignancies and normal renal and hepatic functions. Mezlocillin was administered intravenously over 30 min every 4 h at doses ranging from 12.2 to 125 mg/kg. Blood samples were obtained over one dosage interval at steady state. For all patients, the mean clearance was 0.21 +/- 0.11 liter/h per kg, the mean distribution volume was 0.26 +/- 0.13 liter/kg, and the mean elimination half-life was 0.97 +/- 0.51 h. Trough concentrations were 23.0 +/- 29.9 mg/liter before the dose was administered and 20.4 +/- 27.5 mg/liter at the end of the dosing interval. Peak concentrations averaged 245 +/- 90.4 mg/liter, and average concentrations for the dosing interval were 83.7 +/- 40.4 mg/liter. There were no apparent effects of sex, malignancy, age, or dose on either the kinetic parameters or plasma concentrations. Overall, the disposition parameters for mezlocillin in this patient group were comparable to those reported in adults.
在31名患有恶性肿瘤且肝肾功能正常的儿童（年龄2至19岁）中研究了美洛西林的药代动力学。美洛西林每4小时静脉输注30分钟，剂量范围为12.2至125mg/kg。在稳态下的一个给药间隔内采集血样。所有患者的平均清除率为每千克0.21±0.11升/小时，平均分布容积为0.26±0.13升/千克，平均消除半衰期为0.97±0.51小时。给药前谷浓度为23.0±29.9mg/升，给药间隔结束时为20.4±27.5mg/升。峰浓度平均为245±90.4mg/升，给药间隔的平均浓度为83.7±4mgl升。性别、恶性肿瘤、年龄或剂量对动力学参数或血浆浓度均无明显影响。总体而言，该患者组中美洛西林的处置参数与成人中报道的参数相当。
