Membrne alterations in human glioblastoma.

Plasma membrane-enriched fractions were isolated from human gliomas and brain white matter. These membrane fractions were characterized by electron microscopy and by the distribution of the membrane marker enzymes (Na+K+)-ATPase and 2',3'-cyclic AMP-3'-phosphohydrolase. The comparison of the membranes from tumor and control material by SDS gel electrophoresis reveals an altered tumor membrane. Two proteins of a molecular weight of about 70,000 dalton and 30,000 dalton are found to be more expressed in the tumor membrne.