Bogman M J, Berden J H, Hagemann J F, Maass C N, Koene R A
Am J Pathol. 1980 Sep;100(3):727-38.
Established rat skin grafts carried by immunosuppressed mice were acutely destroyed by an intravenous administration of mouse antirat lymphocyte serum. The histologic pattern of destruction was dependent on the amount of antiserum administered. At low doses (0.01 ml) an Arthus-like reaction was seen with early accumulation of granulocytes. At high doses (0.25 ml) a Shwartzman-like pattern occurred, with early intravascular thrombosis and without evident participation of granulocytes in the initial phases. Groups of mice that received intermediate doses showed graft changes that were transitional between these two types of destruction. Similar histologic patterns have been described in clinical transplantation. Our results show that they are not fundamentally different and that the severity of the triggering reaction determines which of either type will occur.
由免疫抑制小鼠携带的已建立的大鼠皮肤移植物，通过静脉注射小鼠抗大鼠淋巴细胞血清会被急性破坏。破坏的组织学模式取决于所给予抗血清的量。低剂量（0.01毫升）时，可见类似Arthus反应，伴有粒细胞早期聚集。高剂量（0.25毫升）时，出现类似施瓦茨曼反应的模式，伴有早期血管内血栓形成，且在初始阶段无明显粒细胞参与。接受中等剂量的小鼠组显示移植物变化处于这两种破坏类型之间的过渡状态。临床移植中也描述过类似的组织学模式。我们的结果表明，它们在本质上没有差异，触发反应的严重程度决定了会发生哪种类型。
