Mráz M, Faltová E, Sedivý J, Protivová L, Pilný J
Physiol Bohemoslov. 1980;29(4):323-31.
The development of heart lesions induced by isoprenaline (ISO) was quantitatively evaluated by 203Hg-Mercurascan (MSC) which was taken up and retained in the damaged cells. After the administration of ISO, the MSC uptake increased immediately at a constant rate, which was independent of the dose of ISO. A higher cardiotoxic effect of increased doses of ISO was caused by prolongation of the time during which the development of heart lesions proceeded. Later, when the damaged cells were subjected to cytolysis, MSC uptake decreased. The blockade of the effect of ISO by methypranol immediately stopped any further increase of MSC uptake. The accumulation of other labelled substances (Neohydrin, HgCl2, CaCl2) in the damaged myocardium was compared with the uptake of MSC. MSC and HgCl2 in particular are suitable for the observation of early changes; relatively less CaCl2 accumulated in the damaged hearts, but it can be used for the detection of more advanced lesions.
用203Hg - 汞扫描剂（MSC）对异丙肾上腺素（ISO）诱导的心脏病变发展进行定量评估，该扫描剂被受损细胞摄取并保留。给予ISO后，MSC摄取立即以恒定速率增加，这与ISO剂量无关。ISO剂量增加导致更高的心脏毒性作用是由于心脏病变发展持续时间延长。后来，当受损细胞发生细胞溶解时，MSC摄取减少。美普洛尔对ISO作用的阻断立即停止了MSC摄取的进一步增加。将其他标记物质（新双氢氯噻嗪、HgCl2、CaCl2）在受损心肌中的蓄积与MSC的摄取进行了比较。特别是MSC和HgCl2适用于观察早期变化；受损心脏中相对较少积累CaCl2，但它可用于检测更晚期的病变。
