Mráz M, Faltová E, Lincová D, Sedivý J, Gaier N, Mühlbachová E, Cernohorský M, Vrána A
Basic Res Cardiol. 1986 Jan-Feb;81(1):74-82. doi: 10.1007/BF01907429.
Two strains of rats were obtained by selective breeding: the IR strain, resistant to isoprenaline-induced myocardial lesions and the IS strain, sensitive to this damage. The IR rats grew more slowly, the weight of their adipose tissue was higher and the weight of m. soleus was less than that of the IS rats. The IR rats had a higher content of triglycerides in the serum and a lower isoprenaline-stimulated lipolytic activity of adipose tissue in vitro. The basal NEFA level in the serum and its rise after the administration of isoprenaline in vivo did not differ between the strains. The IR rats had a higher content of glycogen in the heart and in the muscle. After the administration of isoprenaline the glycogen content decreased more slowly in IR rats. The findings indicate a considerable importance of the glycogen stores in the heart for the resistance of myocardium to damage.
IR品系，对异丙肾上腺素诱导的心肌损伤具有抗性；IS品系，对这种损伤敏感。IR大鼠生长较慢，其脂肪组织重量较高，比目鱼肌重量比IS大鼠轻。IR大鼠血清中甘油三酯含量较高，体外脂肪组织中异丙肾上腺素刺激的脂解活性较低。两品系大鼠血清中基础非酯化脂肪酸（NEFA）水平及其在体内给予异丙肾上腺素后的升高无差异。IR大鼠心脏和肌肉中的糖原含量较高。给予异丙肾上腺素后，IR大鼠的糖原含量下降得更慢。这些发现表明心脏中的糖原储备对心肌抗损伤具有相当重要的意义。
