宫内节育器女性的痛经。用前列腺素合成酶抑制剂萘普生治疗。
Dysmenorrhea in women with intrauterine contraceptive device. Treatment with a prostaglandin synthetase inhibitor, naproxen.
作者信息
Lalos O, Nilsson B
出版信息
Int J Gynaecol Obstet. 1983 Feb;21(1):33-7. doi: 10.1016/0020-7292(83)90067-x.
Twenty-one women with intrauterine contraceptive devices (IUCD) and severe dysmenorrhea were studied. All the women who participated in the study had primary dysmenorrhea of varying intensities. The insertion of IUCD increased the intensity of dysmenorrheic pain. The effect of naproxen (Naprosyn) on pain alleviation was studied in a double-blind cross-over trial using naproxen and placebo. The effect of naproxen was significantly better than that of placebo (P less than 0.01). No severe side effects occurred during the treatment. There was no difference in the duration and amount of the menstrual blood flow during naproxen treatment compared to placebo according to the women's own judgement.
对21名使用宫内节育器（IUCD）且患有严重痛经的女性进行了研究。所有参与研究的女性均患有不同程度的原发性痛经。宫内节育器的置入增加了痛经的疼痛强度。在一项使用萘普生和安慰剂的双盲交叉试验中，研究了萘普生（萘普酮）对缓解疼痛的效果。萘普生的效果显著优于安慰剂（P<0.01）。治疗期间未出现严重副作用。根据女性自身判断，与安慰剂相比，萘普生治疗期间月经血量和持续时间无差异。
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