Ralph E D, Amatnieks Y E
Antimicrob Agents Chemother. 1980 Mar;17(3):379-82. doi: 10.1128/AAC.17.3.379.
Synergy studies were performed with metronidazole in combination with clindamycin, rifampin, nalidixic acid, ticarcillin, erythromycin, and spectinomycin against Bacteroides fragilis strains. An agar dilution technique was used with two inoculum sizes (10(6) to 10(7) or 10(3) to 10(4) colony-forming units per ml). None of the drugs showed synergy with metronidazole against greater than 50% of the strains, and the synergistic effect was generally less at the larger inoculum. Of the six drugs tested, nalidixic acid, clindamycin, and rifampin showed the most synergy with metronidazole. A partially synergistic or additive effect was the usual interaction occurring between metronidazole and each of the other drugs and no antagonism was seen.
进行了甲硝唑与克林霉素、利福平、萘啶酸、替卡西林、红霉素和壮观霉素联合对脆弱拟杆菌菌株的协同作用研究。采用琼脂稀释技术，接种量有两种（每毫升10⁶至10⁷或10³至10⁴个菌落形成单位）。没有一种药物与甲硝唑联合对超过50%的菌株显示协同作用，并且在较大接种量时协同效应通常较小。在所测试的六种药物中，萘啶酸、克林霉素和利福平与甲硝唑显示出最强的协同作用。甲硝唑与其他每种药物之间通常发生部分协同或相加作用，未观察到拮抗作用。
