与克林霉素、红霉素和甲硝唑相比，交沙霉素和蔷薇霉素对脆弱拟杆菌的体外活性。
In vitro activity of josamycin and rosamicin against Bacteroides fragilis compared with clindamycin, erythromycin, and metronidazole.
作者信息
Santoro J, Kaye D, Levison M E
出版信息
Antimicrob Agents Chemother. 1976 Jul;10(1):188-90. doi: 10.1128/AAC.10.1.188.
Abstract
The inhibitory and bactericidal activities of josamycin and rosamicin against 29 clinical isolates of Bacteroides fragilis were compared with those of clindamycin, erythromycin, and metronidazole by a broth dilution technique. Josamycin and rosamicin had similar inhibitory activity to metronidazole and clindamycin. Rosamicin had similar bactericidal activity to clindamycin but was less bactericidal than metronidazole (the most bactericidal agent tested). Josamycin was slightly more bactericidal than erythromycin (the least bactericidal agent tested), but less so than rosamicin and clindamycin.
摘要
采用肉汤稀释技术，将交沙霉素和蔷薇霉素对29株脆弱拟杆菌临床分离株的抑制和杀菌活性与克林霉素、红霉素和甲硝唑进行了比较。交沙霉素和蔷薇霉素对甲硝唑和克林霉素具有相似的抑制活性。蔷薇霉素与克林霉素具有相似的杀菌活性，但杀菌活性低于甲硝唑（所测试的杀菌活性最强的药物）。交沙霉素的杀菌活性略高于红霉素（所测试的杀菌活性最弱的药物），但低于蔷薇霉素和克林霉素。
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J Infect Dis. 1972 Jul;126(1):104-7. doi: 10.1093/infdis/126.1.104.
2
Metronidazole versus anaerobes. In vitro data and initial clinical observations.
Calif Med. 1972 Dec;117(6):22-6.
3
Treatment of anaerobic bacterial infections with clindamycin-2-phosphate.
Antimicrob Agents Chemother. 1974 Mar;5(3):276-80. doi: 10.1128/AAC.5.3.276.
4
Rosamicin: in vitro activity against anaerobes and comparison with erythromycin.
Antimicrob Agents Chemother. 1976 Feb;9(2):350-1. doi: 10.1128/AAC.9.2.350.
5
Antibiotic susceptibility of the subspecies of Bacteroides fragilis.
Antimicrob Agents Chemother. 1976 Mar;9(3):481-4. doi: 10.1128/AAC.9.3.481.
6
An evaluation of the carbon dioxide component in the GasPak anaerobic system.
J Appl Bacteriol. 1975 Oct;39(2):167-73. doi: 10.1111/j.1365-2672.1975.tb00558.x.
7
Treatment of anaerobic infections with metronidazole.
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8
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