Lulling J, Delwiche J P, Ledent C, Prignot J
Br J Dis Chest. 1980 Apr;74(2):135-41. doi: 10.1016/0007-0971(80)90024-8.
A trial was designed to assess whether repeated administration of ipratropium bromide for two weeks produced greater improvement than was obtained after a single dose. The effect of ipratropium bromide was compared with that of a placebo during a double-blind cross-over randomized trial in patients with advanced chronic airways disease in a stable state. Ipratropium bromide and placebo were both administered by metered dose inhaler for 14 days. There was a slight statistically significant improvement of conductance, thoracic gas volume, FEV1 and VC after inhalation of ipratropium bromide, but repeated doses of the drug did not produce progressive improvement.
一项试验旨在评估，连续两周重复使用异丙托溴铵是否比单次给药能带来更大程度的改善。在一项针对病情稳定的晚期慢性气道疾病患者的双盲交叉随机试验中，将异丙托溴铵的效果与安慰剂进行了比较。异丙托溴铵和安慰剂均通过定量吸入器给药，为期14天。吸入异丙托溴铵后，传导率、胸腔气体容积、第一秒用力呼气容积（FEV1）和肺活量（VC）有轻微的统计学显著改善，但重复给药并未带来渐进性改善。
