使用¹⁴C-脱氧葡萄糖法对亨廷顿舞蹈症动物模型进行代谢改变研究。

Metabolic alterations in an animal model of Huntington's disease using the 14C-deoxyglucose method.

作者信息

Kimura H, McGeer E G, McGeer P L

出版信息

J Neural Transm Suppl. 1980(16):103-9. doi: 10.1007/978-3-7091-8582-7_11.

Abstract

Various brain regions showing altered glucose uptake in an animal model of Huntington's disease (HD) were identified by the 14C-2-deoxyglucose (DG) autoradiographic technique. Rats with kainic acid (KA) lesions of the neostriatum were used as an animal model of HD. KA-injected animals showed reduced utilization of DG in the injected neostriatum as well as in the ipsilateral rostral sulcal cortex, dentate fascia of hippocampus, ventromedial nucleus of the thalamus and cortico-bulbar tract. By contrast, enhanced uptake was found in the ipsilateral globus pallidus, entopeduncular nucleus, the area lateral to the lateral hypothalamus, the lateral habenular nucleus and pars reticulata of the substantia nigra. The results provide interesting in vivo metabolic and functional information on brain circuits involved in motor performance.

摘要

运用¹⁴C-2-脱氧葡萄糖（DG）放射自显影技术，在亨廷顿舞蹈病（HD）动物模型中鉴定出了多个葡萄糖摄取发生改变的脑区。以新纹状体经 kainic 酸（KA）损伤的大鼠作为 HD 动物模型。注射 KA 的动物在注射侧新纹状体以及同侧吻侧沟皮质、海马齿状筋膜、丘脑腹内侧核和皮质延髓束中显示出 DG 利用率降低。相比之下，在同侧苍白球、内苍白球核、下丘脑外侧外侧区域、外侧缰核和黑质网状部发现摄取增强。这些结果为参与运动表现的脑回路提供了有趣的体内代谢和功能信息。