Granberg-Ohman I, Johansson S, Hjerpe A
Mutat Res. 1980 Sep;79(1):13-8. doi: 10.1016/0165-1218(80)90143-3.
To study chromosomal aberrations and the frequency of sister-chromatid exchanges (SCE) a long-term chronic toxicity study was performed in rats treated with phenacetin, phenazone and caffeine, alone and in different combinations. Compared with controls, aberrations such as gaps, breaks and structural dearrangements were only increased in the group treated by phenacetin alone. After mitomycin C treatment of the blood culture, the aberrations were markedly, but not significantly, increased. All experimental groups showed a higher SCE frequency, most deviating in the rats treated with phenacetin alone. This correlates with the fact that phenacetin is a strong general carcinogen.
为研究染色体畸变及姐妹染色单体交换（SCE）频率，对单独使用非那西丁、保泰松和咖啡因以及不同组合处理的大鼠进行了一项长期慢性毒性研究。与对照组相比，单独用非那西丁处理的组中，诸如裂隙、断裂和结构重排等畸变仅有所增加。在用丝裂霉素C处理血培养物后，畸变明显增加，但无统计学意义。所有实验组的SCE频率均较高，单独用非那西丁处理的大鼠中偏差最大。这与非那西丁是一种强致癌物这一事实相关。
