链脲佐菌素诱导的糖尿病大鼠肝脏中高尔基体的形态学
Morphology of the Golgi apparatus in streptozotocin-diabetic rat liver.
作者信息
Sarnecka-Keller M, Kaczmarski F, Kordowiak A
出版信息
Pathol Res Pract. 1980;168(1-3):126-33. doi: 10.1016/S0344-0338(80)80212-3.
The altered morphology of the Golgi apparatus in streptozotocin-diabetic rat liver is described in situ and in preparations of the Golgi-membrane-enriched fraction. The main differences, as compared with controls, are a diminished Golgi apparatus area, the rounding of stacks of cisternae and the absence of secretory vacuoles with VLDL granules. These findings are discussed in view of biochemical alterations found previously in the Golgi-membrane-enriched fraction isolated from streptozotocin-diabetic rat liver.
本文描述了链脲佐菌素诱导的糖尿病大鼠肝脏中高尔基体形态的改变，包括原位观察以及高尔基体膜富集组分的制备观察。与对照组相比，主要差异在于高尔基体面积减小、扁平囊堆叠变圆以及缺乏含有极低密度脂蛋白颗粒的分泌泡。结合先前在从链脲佐菌素诱导的糖尿病大鼠肝脏分离出的高尔基体膜富集组分中发现的生化改变，对这些发现进行了讨论。
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