Commissaris R L, Lyness W H, Moore K E, Rech R H
Pharmacol Biochem Behav. 1980 Oct;13(4):605-8. doi: 10.1016/0091-3057(80)90290-7.
Seven food deprived male rats were trained to press a bar on a fixed ratio-40 (FR-40) schedule of food reinforcement. Administration of 0.5 mg/kg 2,5-dimethoxy-4-methyl amphetamine (DOM) immediately before the start of the session resulted in cessation of responding for some portion of the 40-min test session. Three successive days of p-chlorophenylalanine (PCPA) administration (100 mg/kg) 30 min after each session reduced 5-hydroxytryptamine (5-HT) to 15-26% of control concentrations in various brain regions but did not alter control rates of responding under the FR-40 schedule. Administration of 0.5 mg/kg DOM following this PCPA pretreatment resulted in a greater amount of nonresponding than observed earlier. These data suggest that the effects of the phenethylamine hallucinogen DOM are enhanced by disruption of 5-HT neuronal activity.
七只食物剥夺的雄性大鼠被训练在固定比率为40（FR - 40）的食物强化程序下按压杠杆。在实验开始前立即给予0.5毫克/千克的2,5 - 二甲氧基 - 4 - 甲基苯丙胺（DOM），导致在40分钟测试期的某些时段反应停止。在每次实验后30分钟连续三天给予对氯苯丙氨酸（PCPA）（100毫克/千克），可将5 - 羟色胺（5 - HT）在各个脑区的浓度降至对照浓度的15% - 26%，但并未改变FR - 40程序下的对照反应率。在这种PCPA预处理后给予0.5毫克/千克的DOM，导致无反应的情况比之前观察到的更多。这些数据表明，5 - HT神经元活动的破坏会增强苯乙胺类致幻剂DOM的作用。
