de Saint-Georges L, Eyden B P, Baugnet-Mahieu L, Janowski M, Van Gorp U, Maisin J R
C R Seances Soc Biol Fil. 1980;174(5):840-4.
Two distinct leukemogenic viral subpopulations, BL/F (EL) and BL/F (SL) were derived from RadLV-Rs by propagation in rats. They were purified from the serum and studied by thin section and negative stain electron microscopy. Their ultrastructural organizations were not found to differ significantly from each other or from other murine leukemia viruses for which a detailed model now exists. Our work constitutes to our knowledge a first indepth study of viruses associated with radiation leukemia. It confirms the MuLV model built hitherto exclusively on observations from in vitro grown viruses.
通过在大鼠体内传代，从RadLV-Rs中衍生出了两种不同的致白血病病毒亚群，即BL/F (EL)和BL/F (SL)。它们从血清中纯化出来，并通过超薄切片和负染电子显微镜进行研究。未发现它们的超微结构组织彼此之间或与目前已有详细模型的其他小鼠白血病病毒有显著差异。据我们所知，我们的工作是对与辐射白血病相关病毒的首次深入研究。它证实了迄今仅基于体外培养病毒观察建立的MuLV模型。
