de Saint-Georges L, Baugnet-Mahieu L, Janowski M, Van Gorp U, Maisin J R
C R Seances Soc Biol Fil. 1980;174(5):845-50.
Either a Slow (SL) or Early (EL) type of leukemia are respectively induced in rats by the RadLV-Rs derived BL/F (SL) and BL/F (EL) viral populations. The kinetics of virus propagation was studied comparatively in the thymus, spleen, lymph nodes and bone marrow of rats infected either with BL/F (EL) or BL/F (SL). During the first days after inoculation with BL/F (SL), the viral population increased rapidly in all tissues, reaching a peak at day 8 to 10, except in the lymph nodes which were almost devoid of viral particles. A very different pattern was shown by the EL leukemia, indicating the importance of the early distribution of viruses amongst the lymphoid tissues in view of the further development of the disease. The large amount of viruses observed inside the megakaryocytes and budding from these cells confirm that they play a role in the leukemogenesis.
分别由源自RadLV-Rs的BL/F (SL)和BL/F (EL)病毒群体在大鼠中诱导出慢型（SL）或早型（EL）白血病。比较研究了感染BL/F (EL)或BL/F (SL)的大鼠胸腺、脾脏、淋巴结和骨髓中病毒传播的动力学。在用BL/F (SL)接种后的头几天，病毒群体在所有组织中迅速增加，在第8至10天达到峰值，但淋巴结几乎没有病毒颗粒。EL白血病表现出非常不同的模式，鉴于疾病的进一步发展，这表明病毒在淋巴组织中的早期分布很重要。在巨核细胞内观察到并从这些细胞中出芽的大量病毒证实它们在白血病发生中起作用。
