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给大鼠施用五氯硝基苯与氯化汞或氯化镉的组合,以及六氯苯与氯化汞的组合的毒性。

Toxicities of combinations of pentachloronitrobenzene with mercuric chloride or cadmium chloride, and hexachlorobenzene with mercuric chloride administered to rats.

作者信息

Renner G

出版信息

Xenobiotica. 1980 Jul-Aug;10(7-8):551-6. doi: 10.3109/00498258009033789.

Abstract
  1. Pentachloronitrobenzene (PCNB) and HgCl2, PCNB and CdCl2, and hexachlorobenzene (HCB) and HgCl2 were investigated for their acute oral toxicity in rats, individually and as combinations in various ratios of the organochlorine pesticides to the heavy metal chlorides. 2. The toxicity of mixtures of low dosages of the pairs tested was higher than the sum of the toxicities produced by the individual doses. 3. At increased dosages of the components in the combinations PCNB-HgCl2 and PCNB-CdCl2, the combined lethality tended towards the sums of the effects of the individual doses.
摘要
  1. 分别研究了五氯硝基苯(PCNB)与氯化汞(HgCl2)、PCNB与氯化镉(CdCl2)以及六氯苯(HCB)与HgCl2对大鼠的急性经口毒性,还研究了这些有机氯农药与重金属氯化物以各种比例混合时的毒性。2. 所测试的低剂量组合的毒性高于各单剂量毒性之和。3. 在PCNB-HgCl2和PCNB-CdCl2组合中,各成分剂量增加时,联合致死率趋向于各单剂量效应之和。

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