Renner G
Xenobiotica. 1981 Jul;11(7):435-46. doi: 10.3109/00498258109045854.
This overview of the metabolism of the fungicides hexachlorobenzene (HCB) and pentachloronitrobenzene (PCNB) indicates similarities in their pathways of biotransformation. Several metabolites of HCB and PCNB, such as chlorinated benzenes, the mercapturic acid, thiophenols, thioanisoles and phenols are identical. Both Fungicides initially react with glutathione, with elimination or of the chlorine of the nitro group respectively. The conjugate, S-(pentachlorophenyl)glutathione, is further metabolized by cleavage of the glutamate and glycine results and acetylation of the amino group of the cysteinyl moiety, to give the mercapturic acid N-acetyl-S-(pentachlorophenyl)cysteine, a major metabolite of HCB and PCNB in rats and rabbits respectively, which is further metabolized to simpler sulphur-containing products.
对杀菌剂六氯苯（HCB）和五氯硝基苯（PCNB）代谢的概述表明，它们的生物转化途径存在相似性。HCB和PCNB的几种代谢产物，如氯苯、硫醚氨酸、硫酚、苯甲硫醚和酚类是相同的。两种杀菌剂最初都与谷胱甘肽反应，分别消除或去除硝基的氯。共轭物S-（五氯苯基）谷胱甘肽通过谷氨酸和甘氨酸的裂解以及半胱氨酰部分氨基的乙酰化进一步代谢，分别生成硫醚氨酸N-乙酰-S-（五氯苯基）半胱氨酸，这是HCB和PCNB在大鼠和兔子体内的主要代谢产物，其进一步代谢为更简单的含硫产物。
