Lessard Y, Callec J J, Paulet G
C R Seances Soc Biol Fil. 1980;174(1):52-7.
The cardiotoxicity of high concentrations of inhaled difluorodichloromethane (FC 12) has now been acknowledged. In the present study, the effects of FC 12 on the electrical activity of cells in the atrial and ventricular myocardium of anesthetized rats were recorded with "flexibly mounted" intracellular microelectrodes. The major phenomena observed in both types of cells were: a distinct decrease in the diastolic potential, a decrease inthe amplitude of the action potential, modifications in the shape of the action potential. Analysis of the simultaneously obtained electrocardiogram specifies the rhythm abnormalities which consist of an important decrease in the atrio-ventricular conduction and changes in the myocardial excitability. The cardiotoxicity of FC 12 is assumed to affect passive or active transmembrane ionic movements. Possible mechanisms are suggested here.
高浓度吸入二氟二氯甲烷（FC 12）的心脏毒性现已得到确认。在本研究中，用“柔性固定”的细胞内微电极记录了FC 12对麻醉大鼠心房和心室心肌细胞电活动的影响。在这两种类型的细胞中观察到的主要现象是：舒张电位明显降低、动作电位幅度降低、动作电位形状改变。对同时获得的心电图分析确定了节律异常，包括房室传导显著降低和心肌兴奋性改变。推测FC 12的心脏毒性会影响被动或主动的跨膜离子运动。本文提出了可能的机制。
