Lessard Y, Desbrousses S, Paulet G
C R Seances Soc Biol Fil. 1978;172(2):337-47.
During the inhalation of normally oxygenated gas mixtures containing light or middle concentrations of FC 12, the presence of perfused epinephrine is necessary to induce cardiac arrhythmia in rabbits and dogs. The only inhalation of normally oxygenated gas mixtures containing a very high concentration of FC 12 produces in rabbits and dogs an important decrease in arterial pressure, tachycardia, a fall in respiratory amplitude, an acceleration reflex of respiratory frequency and cardiac arrhythmia. The same experiments in baro and chemodenervated animals show that : respiratory depression due to FC 12 still occurs, but not through the arterial chemoreceptors ; tachycardia has a reflex origin : barodenervation reveals the negative chromotropic effect of FC 12 and increases the fall in arterial pressure, mainly due to the negative inotropic effect of FC 12 ; adrenaline is necessary for FC 12-induced arrhythmia : barodenervation suppresses tachycardia due to the release of endogenous epinephrine and abolishes any arrhythmia.
在吸入含低浓度或中等浓度氟利昂12的正常充氧混合气体时，家兔和犬出现心脏心律失常必须要有灌注的肾上腺素存在。仅吸入含高浓度氟利昂12的正常充氧混合气体时，家兔和犬会出现动脉压显著下降、心动过速、呼吸幅度降低、呼吸频率加快反射及心律失常。对压力感受性反射和化学感受性反射均被阻断的动物进行相同实验，结果显示：氟利昂12引起的呼吸抑制仍然会出现，但并非通过动脉化学感受器；心动过速有反射性起源：压力感受性反射被阻断后，显示出氟利昂12的负性变时作用，并加剧动脉压下降，这主要是由于氟利昂12的负性肌力作用；肾上腺素对氟利昂12诱发的心律失常是必需的：压力感受性反射被阻断后，内源性肾上腺素释放所致的心动过速被抑制，且任何心律失常均消失。
