Paulet G, Lessard Y
C R Seances Soc Biol Fil. 1975;169(4):1048-53.
We have tried to determine if dichlorodifluoromethane (F.C. 12) might have an effect in vitro on the isolated rat and rabbit hearts. The direct action of F.C. 12 on the heart in vitro is similar in both rats and rabbits. It occurs at doses such as 20 +/- 10 mug/ml (rat) and 35 +/- 5 mug/ml (rabbit). F.C. 12 depresses the strength of the myocardial contractions; the effect is reversible at low concentration (less than 60 mug/ml) but irreversible at high concentration (greater than or equal to 120 mug/ml). It also causes a slight bradycardia, but no significant effect on the basal tonus. At high concentration, F.C. 12 may produce arrhythmia : this action occurs more readily in the rat heart than in the rabbit heart.
我们试图确定二氯二氟甲烷（氟利昂12）对离体大鼠和兔心脏是否可能有体外作用。氟利昂12对大鼠和兔离体心脏的直接作用相似。在诸如20±10微克/毫升（大鼠）和35±5微克/毫升（兔）的剂量下会出现这种作用。氟利昂12会降低心肌收缩力；在低浓度（小于60微克/毫升）时该作用是可逆的，但在高浓度（大于或等于120微克/毫升）时是不可逆的。它还会引起轻微的心动过缓，但对基础张力无显著影响。在高浓度时，氟利昂12可能会导致心律失常：这种作用在大鼠心脏中比在兔心脏中更容易发生。
